(solution) BME 282 Biomedical Product Design & Development II

(solution) BME 282 Biomedical Product Design & Development II

I need help with the second question from the assignment. It asks to “write a brief description of the physical process corresponding to that term. Be as specific and biologically accurate as possible in your statements.”

The link below shows the meaning of each term.

https://docs.google.com/presentation/d/1YSIcmLs0EnTivnSJJDhO_YUnoE-3SdnJ7I6pQWYUhvY/htmlpresent

BME 282 ?Biomedical Product Design & Development II Assignment 1: p.1 of 4 Your name: _______________________________________ Person on your left: Person on your right: August 31
September 7
IMPORTANT NOTE: please remember that you should not share any electronic files with classmates.
Summary of design process:
1. In designing your blood glucose meter so that diabetic individuals can test their blood glucose
concentration, you need to know the range over which the meter must be accurate.
a. What is a ?normal? range of blood glucose concentration expected for individuals in good control over
their glucose?
Briefly justify this answer and provide sources of information (include proper citations): b. What is the lowest blood glucose concentration that your meter will measure accurately?
Briefly justify this answer and provide sources of information (include proper citations): c. What is the highest blood glucose concentration that your meter will measure accurately?
Briefly justify this answer and provide sources of information (include proper citations):
2. Have a look at the ?Getting Started in MATLAB? file in the Content section of Blackboard.
Recalling that mass balances take the form ?Accumulation = in ? out + generation ? consumption? for each
of the terms in the attached Matlab model that Dr. Caplan created, which simulates physiologic blood
glucose regulation, write a brief description of the physical process corresponding to that term. Be as
specific and biologically accurate as possible in your statements.
yp(1)
p.meal*exp(-t/p.tau)
– p.bl0*Ci*(Cgb-Cgl)
yp(2)
– p.ls*Cgl BME 282 ?Biomedical Product Design & Development II
p.sl0*Cg*Cgs Assignment 1: p.2 of 4 – p.metabolism
yp(3)
yp(4)
p.insulinbase
p.insulinsynthesis*Idiff
– p.insulindegradation*Ci
yp(5)
p.glucagonbase
p.glucagonsynthesis*Gdiff
– p.glucagondegradation*Cg
3. Dr. Caplan created this model to show normal blood glucose and insulin function. But you could change it
so that it simulates Type I diabetes. Please do that.
What did you change in the model to simulate Type I diabetes? For each change you made, give a succinct
(1-2 lines maximum) description of the change (include numerical values if applicable) and then give a short
paragraph describing the physical phenomenon to which that change corresponds in a Type I diabetic.
Change in model:
Physical phenomenon corresponding to change in model: Change in model:
Physical phenomenon corresponding to change in model: 4. You could also change Dr. Caplan?s mathematical model to simulate Type II diabetes, too. Please do that.
What did you change in the model to simulate Type II diabetes? For each change you made, give a succinct
(1-2 lines maximum) description of the change (include numerical values if applicable) and then give a short
paragraph describing the physical phenomenon to which that change corresponds in a Type II diabetic.
Change in model: BME 282 ?Biomedical Product Design & Development II
Physical phenomenon corresponding to change in model: Assignment 1: p.3 of 4 Change in model:
Physical phenomenon corresponding to change in model: 5. Insert the plots of blood glucose concentration vs. time for normal physiology, Type I diabetes, and Type II
diabetes. Compare (describe similarities) and contrast (describe differences) in these blood glucose
responses to the individual eating a meal.
Normal Physiology Type I diabetes Type II diabetes Insert plot of
blood glucose vs. time
here Insert plot of
blood glucose vs. time
here Insert plot of
blood glucose vs. time
here Compare:
Contrast:
6. Insert the plots of insulin concentration vs. time for normal physiology, Type I diabetes, and Type II
diabetes. Compare (describe similarities) and contrast (describe differences) in these insulin responses to the
individual eating a meal.
Normal Physiology Type I diabetes Type II diabetes Insert plot of
insulin vs. time
here Insert plot of
insulin vs. time
here Insert plot of
insulin vs. time
here BME 282 ?Biomedical Product Design & Development II
Compare: Assignment 1: p.4 of 4 Contrast: 7. Diabetes treatment options affect physiologic glucose regulation.
For each parameter in the mathematical model, there is at least one treatment option that directly affects that
parameter. With the time remaining to you in this class period, learn about some of the treatments used to
control blood glucose in diabetes and describe (as specifically as possible) the impact the treatment would
have on the numerical parameter(s) in the model.
We encourage you to try a simulation or two with each numerical parameter changed to represent treatment
and inclusion of a sketch/plot of those results included in your discussion (with text explaining the effect the
treatment had on the glucose response).
Good sources to start your search for information on treatment options:
http://www.webmd.com/diabetes/guide/default.htm
http://www.diabetes.org/living-with-diabetes/treatment-and-care/
Treatment:
Parameter affected:
How does the treatment affect that parameter (include simulation results where appropriate)?
Treatment:
Parameter affected:
How does the treatment affect that parameter (include simulation results where appropriate)?
Treatment:
Parameter affected:
How does the treatment affect that parameter (include simulation results where appropriate)? Instructions the FALL 2016 semester of BME 282 for turning in Assignment 1:
1. Upload your completed worksheet by the start of class, September 14, 2016
2. Submit a hard copy of your completed worksheet for this assignment AND a Xerox copy of your lab
notebook pages for this assignment at the start of class (9:00 AM) Wednesday, September 14, 2016.
For work that you were unable to accomplish, you may submit the optional explanatory essay. (This
essay must be formally written, high quality, detailed work.)
3. Remember, this is ?an almost exclusively completed in class? assignment. Really.