(solution) A pharmaceutical product is designed to be absorbed in the

(solution) A pharmaceutical product is designed to be absorbed in the

A pharmaceutical product is designed to be absorbed in the gastrointestinal tract. The active ingredient is pressed into a tablet with a density of ? A = 15 kg/m 3 while the remainder of the tab let i s composed of inactive ingredi ents. The partition coefficient is K = 3 × 10 – 2 , and the diffusion coefficient of th e active ingredient in the gas trointestinal fluid is D AB = 0.4 × 10 ? 10 m 2 /s. (a) Estimate the dosage delivered over a time period of 5 h for a spherical tablet of diameter D = 6mm. Hint: Assume the change in the tablet radius over the dosage period is small. (b) Estimate the dosage delivered over 5h for N = 200 small, spherical tablets contained in a gelatin capsule that quickly dissolves a fter inges tion, releasing the medication. The initial mass of the medication is the same as in part (a).